CAS 137525-51-0 Pentadecapeptide BPC 157
Product Name:Pentadecapeptide BPC 157
Alias:Booly Protection Compound 15
CAS NO.:137525-51-0
MF: C62H98N16O22
MW: 1419.53552
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
HPLC Report:>98.462%
BPC 157 is a pentadecapeptide, meaning that is comprised of a chain of 15 amino acids. It has been determined to be a partial sequence of body protection compound (BPC) that can be isolated from gastric juices located in animal test subjects. It possesses a molecular mass of 1419.53552, and its molecular formula is C62H98N16O22. It can be referred to by the alternate names BPC 15, BPC-157, or Booly Protection Compound 15.
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
BPC 157 is a pentadecapeptide, meaning that is comprised of a chain of 15 amino acids. It has been determined to be a partial sequence of body protection compound (BPC) that can be isolated from gastric juices located in animal test subjects. It possesses a molecular mass of 1419.53552, and its molecular formula is C62H98N16O22. It can be referred to by the alternate names BPC 15, BPC-157, or Booly Protection Compound 15.
Increased ligament healing
Has a variety of protective effects in the organs
Human trials demonstrate healing and prevention of stomach ulcers
No adverse reactions have been seen in human trials.
The main characteristics of healing are granulation tissue, angiogenesis and production of collagen. BPC-157 facilitates angiogenesis. Angio (vessel) genesis (formation) is the formation of vessels. No, seriously its that dumb. Take any 2 words, say them out of order in greek and/or Latin and you get the medical term.
BPC-157 acts by modulating Vaso Endothelial Factor (VEGF) which is the factor that causes capillaries to grow into a new area to carry blood and nutrients. This is how healing happens, through blood flow. This only occurred in actual tendon and muscle tissue, in cell cultures BPC-157 did not affect VEGF or healing.
BPC 157 Benifits
BPC 157 has been shown in rat studies to heal torn quadriceps muscles, detached achilles tendon, muscles that have been damaged/crushed
Dramatic fast recovery from muscle tears
Tendon to bone healing
Experiments saw results with oral, peritoneal, and site injections. 10 micrograms per kg was the dose in rats for these results. This means oral or injection makes no difference, with a tiny bit of this healing becomes a whole lot easier.
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Q5 Do you have any reshipment policy？
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In this circumstance we promise reship free to establish long term relationship.
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2.Discreet packing methods.
For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.
3.99.99% customs clearance rate.
We have rich experience in shipping parcel to USA, Australia, UK, Canada, Brazil, Russia, Germany, Poland, Mexico, etc.
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Q1: Have your Product Quality been Approved by the Third Party Lab?
A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2: How do you treat quality complaint?
A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
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Q4: Is there any discount?
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Q7: Do you have any reshipment policy?
Of course, we have the good after-sale service and re-shipment policy if the parcel lose.
Our long association with our clients has brought great benefits, we always take the upmost care in the packaging of our products. Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts, it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish a long term relationship with each other.
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